Background: Constipation and poor sleep quality are most symptoms among patients with chronic kidney disease that affect many individuals worldwide with increasing alarmingly. The research aimed to assess the association between constipation and sleep quality among hospitalized chronic kidney disease patients. Setting: The current research was applied at the inpatient kidney disease department at the Kidney and Urology Hospital, which affiliated to Minia University. Subjects of the research: Purposive sample of 187 patients with chronic kidney disease.  Tools of data collection: Bio-Demographic characteristics, Rome IV diagnostic criteria for functional constipation, the Patient Assessment of Constipation-Symptoms questionnaire and Pittsburgh Sleep Quality Index Results:  There was a statistically significant positive correlation between progression of CKD stages with increasing severity of constipation symptoms, and poor sleep quality. Conclusion: There was a significant association between constipation and sleep quality among patients with CKD. Recommendation: Further investigations regarding epidemiology and prognosis of constipation and sleep quality to evaluate the most effective and safe profiles of different therapeutic techniques for them, and analysis their potential advantages on subsequent results of CKD.