Background: Mastectomy is a traumatic event that leads to a state of a psychological stress, low self-compassion, maladaptive Perfectionism, and shame brought on by a distorted body-image. Aim: This study aimed to explore relation between self-compassion, perfectionism and body image satisfaction among women with mastectomy. Design: A descriptive correlation study was used to achieve the aim of this study. Setting: This study was conducted at general surgery outpatient's clinics at Benha University Hospital. Subject: A total of 100 women with mastectomy participated at this study. Tools of data collection: Researchers used a self-administered questionnaire that included characteristics of women, scale of self-compassion, perfect scale and body self-image scale. Results: Analysis showed that more than half of the studied patients had maladaptive perfectionism related standard subscale and discrepancy subscale. In addition, about two-thirds of the studied patients were unhappy with the appearance and one-third of them were satisfied with appearance. Conclusion: There was high positive correlation between self-compassion, adaptive perfectionism and body image. Moreover, explained that improved self-compassion and adaptive perfectionism had high-frequency positive effects on body image satisfaction. At the same time, maladaptive perfectionism had high-frequency negative effects on body image satisfaction. Recommendations: Implementing psycho-educational program on developing self-compassion and improving adaptive perfectionism of women after mastectomy.