Background: Nurses play a crucial role in helping curb the hazardous health impact of coronavirus disease (COVID-19), their quality of lives, psychological aspect and major functioning has been greatly affected by the pandemic. Aim Evaluate the effectiveness of nursing intervention program on quality of life, Post-traumatic stress symptoms and dispositional resilience among nurses who caring for patients with corona virus at isolation hospitals in Mansoura university hospitals. Method Quasi experimental design, one group pre-test post-test,  convenient sample was conducted among 90 nurses isolation unit at Mansoura university hospital, Dakahlia/Egypt. Tools questionnaire to collect nurse's demographic data, nurses Quality of life SF-12 questionnaires (QoL), Impact of Event Scale Revised (IES-R) and Dispositional Resilience Scale (DRS). Results Total scores of quality of life and DRS domain were improve after implementation of nursing intervention program, while total score of IES-R was decreased after implementation of nursing intervention program, a highly statistically significant positive correlation between total scores of QOL and DRS after the program implementation as (t=0.400, p= 0.019; t=2.400, p=0.019; t=1.503, p=0.037). Conclusion The nursing intervention program tailored to needs is effective in improving nurses' quality of life and dispositional resilience, as well as decrease post-traumatic stress symptoms level. It was recommended to continuous educational program for nurses in clinical area to adapt with stressors through use dispositional resilience to enhance their quality of life. On-the-job continuing nursing education activities should be developed and implemented regularly to respond to nurses' unmet needs.