Propofol is an intravenous anesthetic used for procedural sedation, during monitored anesthesia care, or as an induction agent for general anesthesia. Propofol is almost an ideal IV anesthetic agent, but pain during its injection still remains a problem. The aim of this study was to evaluate the effect of warm application on propofol injection pain among patients undergoing surgeries. Quasi-experimental post-test only non-equivalent groups design was utilized in the current study. The current study was conducted in operating unit at a governmental hospital afflicted to Cairo university hospitals, Cairo, Egypt. A convenient sample of 60 adult male and female patients immediate before surgeries was recruited for the current study. 60 patients were divided to intervention and control group (30 patients in each group). Two tools were used I) personal and medical data tool, II) pain assessment tool. The current study found that; there was not statistically significance difference between study and control group in relation to level of pain, nerve pain and pain radiation.  The current study concluded that; both of warm compresses and lidocine injection as a routine intervention are similar in improving level and characteristics of pain in the site of propofol injection.