Background: Hypertension is a chronic disease and affects the quality of life of patients leading to serious complications if uncontrolled. So those patients need to comply with self-care dimensions to improve their quality of life. The aim of this study was to evaluate the effect of self-care guidelines on quality of life among patients with hypertension. Design: A quasi experimental design. Setting: the study was conducted at medicine outpatient clinics in Ain Shams University Hospital. Study subjects: A purposive sample of adult patients (No=76). Data collection tools: Structured Interview Questionnaire for patients with hypertension, self-care practices questionnaire, and quality of life tool. Results: Regarding to the overall quality of life domains, 40.8% of the studied patients had poor physical, social, psychological, and functional wellbeing pre implementation of self-care guidelines which declined to 17.1% post implementation of self-care guidelines with statistical significant difference (P ≤ 0.05). Conclusion: The implementation of self-care guidelines for patients with hypertension has a statistically significant positive effect on their quality of life (physical, psychological, social, functional wellbeing). Recommendation: This study recommends the importance of initiation of educational programs to increase patients` awareness about self-care practices and manage their disease positively.