Background: Rapid changes occurred all around the globe because of the pandemic crisis. As a result of "covid19," the educational sector had also suffered, and a widespread use of digital tools had accelerated. Aim of this study: to Compare the effect of Online, Traditional and Hybrid Teaching strategies among Obstetrics nursing students on their Perception, Satisfaction, Academic Stress, and Self-efficacy during the Epidemic Covid- 19. Subjects and Methods: Comparative descriptive research design was conducted at Faculty of Nursing -Minia University. Sample: A randomized sample of six hundred students was included in this study. Data were collected through five main tools: Tool I: Interviewing assessment, Tool II: Online learning perception, Tool III: Students' Satisfaction, Tool IV: Academic Stress Scale (ASS) and Tool V: Self-Efficacy scale. Results: The study revealed that the mean age of study students was 21.1 ± 2.5 years, 54.8% of them were females. (58.5%) of traditional group had poor perceptions about quality of technology and effectiveness of online teaching method,74.0% of the traditional teaching group had satisfactory satisfaction with their teaching methods, 80.5% of the online teaching group students had high stress level related to academic expectation, faculty work, and examination, and students' academic self-perception with statistically significant differences (P-Value < 0.001). Conclusion: This study found that most of the students were satisfied with the traditional teaching method, academic stress was present across all three groups (traditional, online, and hybrid), and the greatest levels of stress were found among obstetrics nursing students who had taken the course via the online method with low total perceptions and self-efficacy. Recommendations: Faculties should prioritize hybrid learning that focuses on raising students' success and accommodates their unique learning styles. Both educators and students would benefit much from specialized training programs in the use of computers and internet and the management of the faculties should make concerted efforts to facilitate this development providing educators with the resources they need to reduce student stress in the classroom via the use of hybrid learning and other strategies. Additional research on the connection between hybrid learning and academic success may be conducted.