Background: Children are extremely vulnerable to scalds injury, so empowering mothers regarding scalds injury make them able to play an important role in targeting interventions to those at greatest risk. The study aimed to evaluate the effect of mothers' empowerment program on knowledge, practices, and attitude toward their children scalds injury. Research design: A quasi-experimental research (one group pre/post test) design was used. Setting: Maternal and Child Health Center in Kafrelsheik city and the Pediatric Outpatient Clinics at Kafrelsheik general hospital. Sample: A convenient sample of 113 mothers were participated in the study. Tools: Two tools were uesed in data collection, first tool, structured interviewing questionnaire consisted of mothers' demographic characteristics, mothers' knowledge about scalds injuries, mothers' reported Practices. Second tools, mothers' attitudes toward scalds injury. Results: Study finding represents that pre program implementation about 6.2% of mothers had a good level of knowledge and improved to 57.5% post-program implementation (P= 0.001), there were highly significant differences between mothers' reported practices, pre & post empowerment program with p <0.001, according to mother' attitude, there were highly significant differences between mothers' attitudes about scalds injury pre /post empowerment program at (<0.001). Conclusion: The current study indicated that, there were highly significant improvement of mothers' knowledge, pracices and attitude post empowerment program. Recommendations: Periodic counseling program should be done for mothers of children about scalds injury prevention at Maternal and Child Centers.