Background: Pressure ulcers continue to be one of the most prevalent conditions in patients with orthopedic disorders, followed by immobilization. Aim: To evaluate the effect of pressure ulcer prevention through applying evidence-based nursing interventions for patients with orthopedic disorders. Setting: This study was implemented at the orthopedic department of Menoufia University Hospital, Egypt. Methods: A research design experiment was used in this study. A sample of 80 adult patients was randomly selected and split into two equal groups of 40 patients each. Three tools were utilized to collect data: tool (I): The Scio demographic and clinically structured interview questionnaire, including demographic data, personal hygiene, and a skin assessment observation check list (pressure ulcer signs and symptoms). (Tool 2): Predicting pressure sore risk using the Braden Scale (tool 3): The Numeric Pain Rating Scale. The results: The data analysis revealed that the intervention group had a statistically significant reduction in pain, redness, and edema of the skin in the study areas compared with the control group at the post-intervention period. As a result, the incidence of pressure ulcers among the study group was lower than in the control group. This means that the implementation of the evidence-based nursing interventions could prevent the occurrence of pressure ulcers in the intervention group. Conclusions: Implementation of an evidence-based nursing intervention could prevent the occurrence of pressure ulcers among the hospitalized patients in the orthopedic ward. Recommendations: Preventing pressure ulcers through evidence-based nursing interventions should be applied to an area of the skin in patients at risk for pressure ulcers.