Background: Knowledge-sharing (KS) is a voluntary activity that is mostly dependent on an individual's desire to share knowledge, their ability to direct the process of sharing knowledge, and their participation in KS activities. Those who actively engage in knowledge sharing are motivated to exhibit innovative behavior with the newly acquired knowledge. There is substantial practical evidence on the significant influence of KS towards innovative work behavior (IWB). Aim: To investigate the consequence of KS training program on staff nurses' innovative work behavior (IWB). Methods: This Quasi- experimental: pretest-post-experienced design was performed at all medical and critical care units (CCU) at Ain Shams University Hospital which included 98 staff nurses which were randomly selected out of 300 staff nurses. Data was collected using a Self-administered knowledge questionnaire, KS-readiness questionnaire, and Innovative Behavior Inventory. Results: Results showed that staff nurses' knowledge and KS readiness were enhanced in the post-intervention and follow-up stages. Furthermore, staff nurses' total IWB was highly significant variation in post-intervention and follow-up stages when compared with pre-intervention stage. Conclusion & Recommendation: according to the findings of this study it is concluded that KS educational program had positive consequence on staff nurses' total IWB in post and 3 months from the intervention compared to the pre-intervention stage. The study suggests that organizations can offer culture that supports sharing of information and learning together. Nurse leaders must support shared learning and ask to create infrastructures that facilitate KS. Enhancing tools that encourage KS in clinical practice and encouraging nurses to innovate.