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392665

A Rare Case of Aspergillosis of Cranial Bone Flap in an Immunocompromised Patient: A Case Report

Article

Last updated: 24 Dec 2024

Subjects

-

Tags

Infectious diseases

Abstract

Fungal infections of cranial bone flaps are rare but potentially life-threatening complications in immunocompromised patients undergoing neurosurgery. Aspergillus niger, though less common than other Aspergillus species in clinical settings, can cause severe opportunistic infections.
We report a case of a 60-year-old immunocompromised female who developed an Aspergillus niger (A. niger) infection of the cranial bone flap three months after pterional craniotomy for aneurysm clipping. The patient presented with a chronic discharging sinus at the surgical site. Diagnostic imaging revealed an epidural collection, and microbiological examination confirmed A. niger infection.
Treatment involved surgical debridement with bone flap removal and long-term voriconazole therapy. The patient showed clinical improvement over 4-5 weeks and remained infection-free at 12-month follow-up.
This case highlights the importance of considering fungal pathogens in delayed post-neurosurgical infections, especially in immunocompromised patients. Prompt diagnosis and aggressive management with combined surgical and antifungal therapy are crucial for favourable outcomes.

DOI

10.21608/aeji.2024.321612.1411

Keywords

Aspergillosis, Aspergillus niger, Cranial bone flap infection, central nervous system, Fungal brain abscesses

Authors

First Name

Sheetal

Last Name

Goenka

MiddleName

-

Affiliation

Department of Microbiology Institute: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Delhi, India.

Email

drsheetalgoenka@gmail.com

City

New Delhi

Orcid

0000-0001-8033-8391

First Name

Wanshisha

Last Name

Wanswett

MiddleName

D

Affiliation

Department of Microbiology Institute: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Delhi, India.

Email

wanshiwansh@gmail.com

City

New Delhi

Orcid

-

First Name

Bibhabati

Last Name

Mishra

MiddleName

-

Affiliation

Department of Microbiology Institute: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Delhi, India.

Email

bibham89@yahoo.com

City

New Delhi

Orcid

-

First Name

Poonam

Last Name

Loomba

MiddleName

-

Affiliation

Department of Microbiology Institute: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Delhi, India.

Email

drpoonam68@gmail.com

City

New Delhi

Orcid

-

First Name

Manisha

Last Name

Jain

MiddleName

-

Affiliation

Department of Microbiology Institute: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Delhi, India.

Email

manisha_jain29@yahoo.com

City

New Delhi

Orcid

0000-0002-6976-3853

First Name

Abha

Last Name

Sharma

MiddleName

-

Affiliation

Department of Microbiology Institute: Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), Delhi, India.

Email

abha_sh79@rediffmail.com

City

New Delhi

Orcid

-

Volume

14

Article Issue

4

Related Issue

51602

Issue Date

2024-12-01

Receive Date

2024-09-18

Publish Date

2024-12-01

Page Start

504

Page End

509

Print ISSN

2090-7613

Online ISSN

2090-7184

Link

https://aeji.journals.ekb.eg/article_392665.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=392665

Order

12

Type

Case report

Type Code

622

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

A Rare Case of Aspergillosis of Cranial Bone Flap in an Immunocompromised Patient: A Case Report

Details

Type

Article

Created At

24 Dec 2024