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361303

Study of CD64 and HLA-DR as Early Detection Markers of Sepsis in Hepatic ICU Patients

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Hepatology

Abstract

Background and study aim: Sepsis is the most common cause of death in liver cirrhosis patients. Aim: Evaluation of neutrophil and monocyte CD64 and HLA-DR as early biomarkers predicting sepsis in liver cirrhosis.
Patients and Methods: This case-control study involved 70 cirrhotic patients (35 with sepsis and 35 without) and 30 healthy individuals. Laboratory studies were performed, including CD64 and HLA-DR using flow cytometry along with sepsis index (SI).
Results: Patients were mainly males (80%), aged 62.17 ± 7.56, and 64.69 ± 11.64 years in group 1&2 respectively. Mono CD64% at Cut-off: >62.9 showed AUC: 0.676, Sensitivity: 80.0%, Specificity: 60.0%, PPV: 66.7%, and NPV: 75.0%, while Mono CD64 MFI at Cut-off >9.5 showed AUC: 0.659, Sensitivity: 94.29%, Specificity: 37.14%, PPV: 60.0%, and NPV: 86.7%. Combinations of CRP+ Lactate+ Mono CD64%+ Mono revealed AUC: 0.929, Sensitivity: 82.86%, Specificity: 91.43%, PPV: 90.6%, and NPV: 84.2% Mono CD64% and CD64 MFI (0.003; 0.03] respectively.
Regression analysis defined Mono CD64% >62.9 (OR 6], Mono CD64 MFI >9.5 (OR 9.75) CRP >32.4 (OR 13.5), lactate>1.93 (OR 12.08) and ALBI score>0.01 (OR 6) all as factors affecting early sepsis in cirrhosis.
Conclusion: Mono CD64% and Mono CD64 MFI proved efficacy as early septic biomarkers with higher efficacy when combined with traditional inflammatory markers in liver cirrhosis patients.

DOI

10.21608/aeji.2024.282942.1379

Keywords

Mono CD64, HLA-DR, Sepsis, Liver cirrhosis, decompensated

Authors

First Name

Maha

Last Name

Elsabaawy

MiddleName

-

Affiliation

Hepatology and Gastroenterology department, National Liver Institute, Menoufia University Shebeen El-Kom, Egypt

Email

maha.ahmed@liver.menofia.edu.eg

City

shebeen elkoom

Orcid

-

First Name

Gasser

Last Name

Elazab

MiddleName

-

Affiliation

Hepatology and Gastroenterology department, National Liver Institute, Menoufia University Shebeen El-Kom, Egypt

Email

g_elazab@yahoo.com

City

shebeen elkoom

Orcid

-

First Name

Fatma

Last Name

Khalil

MiddleName

-

Affiliation

Microbiology and Immunology department, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt

Email

fatmakhalil288@gmail.com

City

Shebin El-Kom

Orcid

-

First Name

Fatama

Last Name

Alhajajy

MiddleName

-

Affiliation

Internal Medicine department, Faculty of medicine, Misr University For Science and Technology, Cairo, Egypt.

Email

fatma.alhajajy@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Awadien

MiddleName

-

Affiliation

Internal Medicine department, Faculty of medicine, Misr University For Science and Technology, Cairo, Egypt.

Email

mohamed.awadein@must.edu.eg

City

-

Orcid

-

First Name

Fatma

Last Name

Abd Elmaksoud

MiddleName

-

Affiliation

Clinical and Chemical Pathology department, Faculty of medicine, Cairo University, Cairo, Egypt

Email

fatma.abdelwahab@cu.edu.eg

City

-

Orcid

-

First Name

Mervat

Last Name

Abdelkareem

MiddleName

-

Affiliation

Hepatology and Gastroenterology department, National Liver Institute, Menoufia University Shebeen El-Kom, Egypt

Email

dr.mervat82@yahoo.com

City

shebeen elkoom

Orcid

-

Volume

14

Article Issue

3

Related Issue

49910

Issue Date

2024-09-01

Receive Date

2024-05-10

Publish Date

2024-09-01

Page Start

287

Page End

297

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 14_Issue 3_Pages 287-297.pdf

PDF . 470.0kB

Link

https://aeji.journals.ekb.eg/article_361303.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=361303

Order

5

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

Study of CD64 and HLA-DR as Early Detection Markers of Sepsis in Hepatic ICU Patients

Details

Type

Article

Created At

24 Dec 2024