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354968

Role of Neutrophil Lymphocyte Ratio in Prediction of Disease Activity in Ulcerative Colitis Disease

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Gastroenterology

Abstract

Background and study aim: None of Serum biomarkers that are utilized for diagnosis and evaluating ulcerative colitis (UC) disease activity is specialized for intestinal inflammation. Thus, it is preferable to have access to simple, low-cost techniques for evaluating disease activity. Aim of the study is to examine whether neutrophil lymphocyte ratio (NLR) levels are changed in UC patients and to know its potential as a simple, affordable, and accessible predictor of ulcerative colitis patients' disease activity.
Patients and Methods: This cross-sectional analytic study involved 62 UC patients and 31 volunteers as a control group. All degrees of disease activity and severity were included. Physician global assessment as well as patient's overall Mayo Score. Colonoscopy with a confirmation biopsy and Mayo endoscopic score was calculated. NLR, serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and Fecal calprotectin (FC) were measured in all subjects.
Results: NLR was significantly higher in active patients (4.3±2.4) compared to inactive patients (1.7±1.1) and control group (1.8±0.7) with P-value of Conclusion: NLR is strongly correlated with disease activity in patients having UC, and it is more accessible and affordable than many other non-invasive indicators.

DOI

10.21608/aeji.2024.354968

Keywords

ulcerative colitis, activity, inflammatory bowel disease, Neutrophil lymphocyte ratio

Authors

First Name

Ahmed

Last Name

Taha

MiddleName

E

Affiliation

Endemic medicine department, Faculty of medicine, Cairo university, Cairo, Egypt.

Email

a.tahaa85@cu.edu.eg

City

Cairo

Orcid

0000-0003-1597-8303

First Name

Dina

Last Name

Abd Elsayed Mohamed

MiddleName

F

Affiliation

Endemic medicine department, Faculty of medicine, Cairo university, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Menna-t-Allah

Last Name

Saad El Dine

MiddleName

G

Affiliation

Pathology department, Faculty of Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

Fady

Last Name

Zaki Rizk

MiddleName

F

Affiliation

Endemic medicine department, Faculty of medicine, Cairo university, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Abbas

MiddleName

B

Affiliation

Integrated clinical and research center for intestinal disorders (ICRID), Faculty of Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

Mennatallah

Last Name

Rashwan

MiddleName

A

Affiliation

Integrated clinical and research center for intestinal disorders (ICRID), Faculty of Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

Tamer

Last Name

ElTantawy ELbaz

MiddleName

M

Affiliation

Endemic medicine department, Faculty of medicine, Cairo university, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Negm

MiddleName

I

Affiliation

Integrated clinical and research center for intestinal disorders (ICRID), Faculty of Medicine, Cairo University.

Email

-

City

-

Orcid

-

Volume

14

Article Issue

2

Related Issue

47756

Issue Date

2024-06-01

Receive Date

2024-03-27

Publish Date

2024-06-01

Page Start

194

Page End

205

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 14_Issue 2_Pages 194-205.pdf

PDF . 573.6kB

Link

https://aeji.journals.ekb.eg/article_354968.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=354968

Order

6

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

Role of Neutrophil Lymphocyte Ratio in Prediction of Disease Activity in Ulcerative Colitis Disease

Details

Type

Article

Created At

24 Dec 2024