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353390

Clinicoepidemiologic Study of Hepatocellular Carcinoma among HCV Induced Compensated Cirrhotic Patients who Achieved Sustained Virologic Response with Direct Acting Antiviral Dru

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Hepatology

Abstract

Background and study aim: Hepatocellular carcinoma (HCC) is a major complication of hepatitis C virus (HCV) induced liver cirrhosis. Cirrhotic patients who achieved sustained virologic response (SVR) after DAAs remain at risk of HCC.
Patients and Methods: This cross-sectional study, carried out at hepatitis viruses' treatment unit affiliated to Al Ahrar teaching hospital in Sharkia governorate, Egypt in the period between 2017 and 2022 on 440 HCV induced compensated cirrhotic patients who received DAAs for treating HCV and had achieved SVR.
Results: By the end of the study, 110 out of 440 (25 %) patients developed de novo HCC. Risk factors for HCC were old age, male gender, rural residence, and diabetes mellitus. Clinical, laboratory and radiologic features of this type of HCC were similar to those of HCC in general.
Conclusion: Frequency of HCC is still high among DAAs treated HCV induced compensated cirrhotic patients with SVR and the 6 monthly follow up by AFP and pelviabdominal ultrasound in these patients is mandatory.

DOI

10.21608/aeji.2024.264655.1352

Keywords

HCV, Chronic hepatitis C, DAAs, SVR and HCC

Authors

First Name

Dina

Last Name

Abdallah

MiddleName

G

Affiliation

Tropical Medicine Department, Al Ahrar Teaching Hospital, Sharkia, Egypt.

Email

gamaldina189@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Farghaly

MiddleName

Emam

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Email

mohammedemam59@icloud.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdelmaksoud

MiddleName

A

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Email

monaya3kop@yahoo.com

City

-

Orcid

-

First Name

Mai

Last Name

Ghanem

MiddleName

Saad

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Email

mai2014.mg@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Mohamed

MiddleName

Abdallah

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Email

dr.traveller_2000@yahoo.com

City

-

Orcid

-

First Name

Ibrahim

Last Name

Ibrahim

MiddleName

M

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

Email

ibrahimibrahim1979@yahoo.com

City

-

Orcid

-

Volume

14

Article Issue

2

Related Issue

47756

Issue Date

2024-06-01

Receive Date

2024-02-28

Publish Date

2024-06-01

Page Start

173

Page End

183

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 14_Issue 2_Pages 173-183.pdf

PDF . 491.7kB

Link

https://aeji.journals.ekb.eg/article_353390.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=353390

Order

4

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

Clinicoepidemiologic Study of Hepatocellular Carcinoma among HCV Induced Compensated Cirrhotic Patients who Achieved Sustained Virologic Response with Direct Acting Antiviral Drugs.

Details

Type

Article

Created At

24 Dec 2024