Leishmaniasis is a parasitic disease caused by an intracellular protozoon of genus Leishmania and is transmitted by the vector – sandfly. It is an endemic disease in many tropical countries like India. The clinical spectrum of Visceral Leishmaniasis (VL) varies from asymptomatic to severe forms depending on the immune status of the host. When the immune system is suppressed, there are high chances for relapses or reactivation of the disease; which is very rare in immunocompetent hosts. Here, we report a case of second time relapse of VL in a young immunocompetent male with no comorbidities, despite appropriate treatment of VL with liposomal amphotericin B. (L-Amb).