Background and study aim: Metabolic-dysfunction Associated Fatty Liver Disease ( MAFLD) caused by multiple risk factors like obesity, hepatitis C virus infection, and diabetes mellitus . One of the most important risk factors which may be implicated in MAFLD is thyroid dysfunction due to its important effects on hepatic fatty acid and synthesis of cholesterol. So, in this study we aimed to assess the association between thyroid dysfunction and MAFLD in Egyptian patients.
Patients and Methods: ‎‎‎ This study was  carried out on 100 patients who attended to Tanta tropical medicine outpatient clinic. They were older than 18 years fulfilling the criteria of  MAFLD and thyroid functions were done for them ‎.‎
Results: There were 67% cases euthyroidism, 29% cases subclinical hypothyroidism(SCH) and 4% cases overt hypothyroidism. The number of females with subclinical hypothyroidism were 22(40%) but males were  7 (15.6%). Overt hypothyroidism was present in 4(7.3%) females ,but in males was 0‎.
Conclusion: One of the most common endocrine abnormalities which may be present in MAFLD patients is thyroid dysfunction particularly subclinical hypothyroidism especially in females ‎‎.