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307734

Serum Levels of Interleukin-17 in Patients with Human Papillomavirus Infections: A Case Control Study ‎‎

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases

Abstract

Background and study aim: Human papilloma virus (HPV) is the most common cause of cutaneous warts and mucosal papillomas and high-risk types of it are involved in developing genital, oropharyngeal, and colorectal malignancies. Interleukin-17 (IL-17), expressed by T helper 17 (Th17) cells, is crucial for inducing a protective immune mechanism against various infections. The purpose of this study was to evaluate serum IL-17 levels in patients with HPV infections compared to healthy controls.
Patients and Methods: ‎‎‎ A total of 40 patients with cutaneous warts or mucous membrane papilloma and 20 healthy controls were included in this case-control study. Using enzyme-linked immunosorbent assay (ELISA) kits, serum IL-17 levels were assessed in both groups‎.‎
Results: Serum IL-17 levels were significantly higher in patients with HPV infection compared to healthy controls (P=0.004). Moreover, there was a significant positive correlation between serum IL-17 level and lesion duration‎.
Conclusions: IL-17 may play a role in the chronicity of HPV infections ‎‎.

DOI

10.21608/aeji.2023.214341.1293

Keywords

Human papillomavirus, DNA virus, Papilloma, IL17, ELISA

Authors

First Name

Emad

Last Name

Moustafa

MiddleName

A

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.‎‎

Email

dr.emad2004@gmail.com

City

-

Orcid

-

First Name

Reham

Last Name

Essam

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.‎‎

Email

rereessam22@gmail.com

City

-

Orcid

-

First Name

Rana

Last Name

Ehab

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.‎‎

Email

ranaehab015@gmail.com

City

-

Orcid

-

First Name

Maha

Last Name

Khater

MiddleName

W

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

mahakhatermicro@gmail.com

City

-

Orcid

-

First Name

Amr

Last Name

El Hawary

MiddleName

T

Affiliation

Department of Internal Medicine (Hepatogastroenterology unit), Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

dramrelhawary@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Sharaf

MiddleName

L

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.‎‎

Email

drahmedsharaf77@gmail.com

City

-

Orcid

0000-0003-0318-0783

Volume

13

Article Issue

3

Related Issue

43043

Issue Date

2023-09-01

Receive Date

2023-05-30

Publish Date

2023-09-01

Page Start

157

Page End

164

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 13_Issue 3_Pages 157-164.pdf

PDF . 593.8kB

Link

https://aeji.journals.ekb.eg/article_307734.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=307734

Order

3

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

Serum Levels of Interleukin-17 in Patients with Human Papillomavirus Infections: A Case Control Study ‎‎

Details

Type

Article

Created At

24 Dec 2024