Granulicatella species were previously known as nutritionally variant streptococci, which are now classified in two new genera, the Abiotrophia and Granulicatella. Granulicatella adiacens (G. adiacens) is a part the normal commensals of human mucosal surfaces, including oral cavity, urogenital and gastrointestinal tract and rarely causing disease. They grow in Gram-positive cocci in pairs and chains, difficult to be identified by conventional methods, since this species require pyridoxal-supplemented culture media for optimal growth. We report a case of bacteremia caused by G. adiacens in an elderly male suffering from hepatocellular carcinoma. The infection was diagnosed, the patient was treated successfully and eventually discharged. G. adiacens is an opportunistic infection in immunocompromised patients especially neutropenic or patients with comorbid conditions as diabetes or other systemic illnesses, particularly if they required long hospitalization and intensive care unit admission. Infection rate may be underestimated either unidentified or misidentified, since the organism necessitates automated identification.