Background and Aim of the study: HCV infection affects about 30% of HIV-positive individuals. Most people agree that HIV accelerates the progression of chronic liver diseases caused by HCV. On other hand there is a lack of clarity regarding how HCV affects HIV infection and disease progression‎.‎ the study was carried out to evaluate the impact of HCV coinfection on HIV Egyptian patients as regard progress of the disease, response to therapy, comorbid conditions and mortality rates
Patients and Methods: ‎‎‎ This study was medical record based for 2 years as a multicenter retrospective Cohort study that compared 67 patients of HIV & HCV coinfection with 219 patients of HIV infection ‎.‎
Results: HIV infection and HIV&HCV coinfection are more common in male than female, the common mode of HIV infection were , heterosexual, homosexual, and drug users, with no significant difference between the  two groups. There was a statistically significant difference between the two groups regarding the AST level and the mean baseline CD4 level. There is no difference between 2 groups as regard response to antiretroviral treatment. The percentage of change in the CD4 level was statistically significantly higher in the HIV group, after treatment. No statistically significant difference between the two groups regarding the overall survival analysis. Increased ALT level, basal CD4 level, and adherence to treatment were shown as independent predictors for negative PCR-HIV‎.
Conclusion: HIV has no effect on treatment of HCV infection while HCV infection has negative impacts on HIV patients' ability to recover their CD4 cells ‎‎.