Background: Liver cirrhosis is characterized by multiple metabolic changes. Hepatitis C virus (HCV) induced cirrhosis is one of the universal causes of morbidity and mortality. The peak prevalence of antibodies to hepatitis C virus (HCV) was reported in Egypt. The aim of this study was to evaluate lipid profile in patients with hepatitis C virus induced liver cirrhosis‎‎.
Study aim: To evaluate lipid profile in patients with hepatitis C virus induced liver cirrhosis.
Patients and Methods: This Case control study was conducted on 63 subjects divided into 21 subjects in each of 3 groups: Chronic hepatitis C group, cirrhotic groups and healthy control group. Full history taking and  examination were done for all cases.  Fasting serum lipid profile of serum total cholesterol , TG ,  HDL, LDL, VLDL were measured for all cases‎‎‎‎‎‎‎.
Results: There was statistically significant difference between the studied groups regarding total cholesterol and HDL cholesterol, TG and VLDL cholesterol. The best cutoff of HDL cholesterol in diagnosis of presence of liver cirrhosis was ≤37.71 mg/dl with area under curve 0.745, sensitivity 71.4%, specificity 71.4%, positive predictive value 55.6%, negative predictive value 83.3%m accuracy 71.4%. The best cutoff of VLDL cholesterol in diagnosis of presence of liver cirrhosis is ≤21.423 mg/dl with area under curve 0.78, sensitivity 84.5%, specificity 75.0%, positive predictive value 63.3%, negative predictive value 90.2%m accuracy 78.5%. Significant AUC was recorded with cutoff regard Serum cholesterol, Serum triglycerides, LDL and VLDL ≤157.5, ≤152.9, ≤83.2 and ≤30.59 respectively with perfect validity.
Conclusion: lipid parameters may be considered as a supporting method in appraising hepatic illness ‎‎‎‎‎‎‎.