This work studied the effect of treatments of cellulose acetate (CA) fabric with nano titanium dioxide Nano-particles (TiO2 NPs) in alcoholic media and combined excimer laser/ TiO2 NPs on the fabric printability with both disperse and turmeric natural dye. The cellulose acetate fabric was treated with various concentrations of TiO2 NPs (0.3-1.0 % o.w.f) using a padding technique, squeezing to 100 % pick up and then cured thermally at 110 0 C for 5 min or via subjecting to microwave irradiation for 60s. The treated cellulose acetate was printed with both C. I. Disperse Red 167 and turmeric natural dyes. The printability of the treated CA fabric was evaluated by measuring the colour strength (K/S) as well as the fastness properties. The results showed that treatment with TiO2 NPs in alcoholic media as well as laser/ TiO2 NPs improved the printability of CA fabric with the both disperse and turmeric dyes. The treatment with TiO2 NPs in ethanol solution of concentration 50% (v/v) after laser treatment resulted in highest colour strength and colour fastness. The use of turmeric dye, padding methodology for treatment as well as laser irradiation gives high potential for enhancing printability of cellulose acetate fabric with natural dyes and provides a sustainable and friendly technique as an alternative to disperse dyes.