This study aims to investigate the lyocell fabric which become very popular in recent times among the researcher due to its higher strength, rigid crystalline morphology, being completely non-toxic, biodegradable manufactured by an eco-friendly non-polluting process, and its proximity to cotton. This study exhibits the effect of both synthetic dyes and natural dyes on lyocell fabric. Synthetic dyes include reactive dyes and vat dyes, while natural dyes include pomegranate peel dyes, Mexican marigold flowers, and gardenia dyes. Also dyeing lyocell with blended fabrics such as cotton and silk and polyamide. This study aims to investigate the lyocell fabric which become very popular in recent times among the researcher due to its higher strength, rigid crystalline morphology, being completely non-toxic, biodegradable manufactured by an eco-friendly non-polluting process, and its proximity to cotton. This study exhibits the effect of both synthetic dyes and natural dyes on lyocell fabric. Synthetic dyes include reactive dyes and vat dyes, while natural dyes include pomegranate peel dyes, Mexican marigold flowers, and gardenia dyes. Also dyeing lyocell with blended fabrics such as cotton and silk and polyamide.