knitted fabrics are very special and sensitive fabrics where any change in its specifications will affect all its properties and end uses. The weft knitted fabrics are the most suitable fabrics for daily clothes specially with children garment, because of knitted fabric properties like softness, stretching so it is easy deformation and comfortable to children Moving. Fabric structure and fabric weight are the most important fabric specifications which direct effect on all fabric properties, also they are one of the most important factors which determine the fabrics end use. This paper presents a study of the effect of weft knitted fabric variables using different cotton fabric structure and weight/ unit area on children garment properties. It was studied some of properties which will be suitable to the children clothes durability like Penetration force and Bursting strength, Also the properties which related to the children clothes' comfort like Wick ability and air permeability. The data analysis concluded that both of the tested parameters are significant, but fabric structure is more effective than weight/ unit area on the most properties