Background: Electronic health (eHealth) is one of emerging domains, which offer the use of information and communication technology, internet as well as other related technologies to enhance health care delivery and service provision. Aim: This study aimed to assess knowledge, attitude, and practice of eHealth among Egyptian health care providers. Subjects and Methods: This is a multicentric cross-sectional analytical study conducted at university hospitals in Egypt. The study was approved by the Institutional Review Board (IRB) committee of the Faculty of Medicine, Cairo University (N-64-2022). Health care providers including physicians and nurses across the different specialties were invited to fill the pre-tested structured self-administered e-questionnaire. Results: The overall response rate was 97.2% (418 healthcare provider responded from 430 invited). Age of respondents' mean was 34.2 ± 10.9 years. Females represented more than three quarters of the taken sample (78.5%). The current study revealed that (44%) of the participants had good level of knowledge while most of them (83%) had a favorable attitude towards eHealth. Medical literature and electronic media significantly raised attitude score among participants, while ever attendance of orientation training program on eHealth significantly raised both knowledge and attitude scores. Attitude score % (median= 90, IQR: 70-100) was higher than knowledge score % (median= 70, IQR: 60-90), with moderate positive significant correlation (r= 0.34, p < /em>= 0.001). Conclusion: The current study shed light on different enablers of eHealth adoption among healthcare providers. Medical literature, electronic media and orientation training program played pivotal role in raising both knowledge and attitude towards eHealth.