Background: At the end of 2019, Wuhan, China, became the center of the COVID-19 coronavirus (SARS-CoV2) infectious illness pandemic. The first incidence in Egypt was reported on March 2, 2020. The (WHO) quickly proclaimed the outbreak a global pandemic. In addition to other measures to prevent the spread of this extremely contagious illness, the Egyptian Ministry of Health required the use of facial masks by the general populace. In both the general public and healthcare workers, it has been observed that wearing facial masks on a regular basis and for an extended period of time has caused the development of numerous skin issues and facial dermatitis, including new-onset acne and flare-ups of pre-existing acne. Objective: Determine the incidence of maskne among universities. Subjects And Methods: A total of 1011 university students were enrolled. Questionary. Results: 565 (55.9%) were females and 446 (44.1%) were males, and the predominant age group was 22.33 ±1.79 years old. The majority of participants wore a mask for less than 4 hours 355 (47.8). The surgical masks were the most frequently used masks, 307(41.4%). 408 (96.7%) of 422 participants had a previous family history of acne. 181 (95.3) participants were smokers and had acne. Cigarettes were the commonest type. The majority of our participants who received COVID vaccination developed acne 538 (97.8). The majority of our participants who had regular cycles developed acne 352 (96.2). Conclusion: At the end, the findings of our study indicated a substantial correlation between the use of face masks often and the development of a fresh outbreak of acne.