Background: Changes in the endometrial microenvironment seen in chronic endometritis (CE) might impair endometrial receptivity, potentially leading to female infertility. Studies indicate that chronic endometritis is often identified in women experiencing infertility, especially those with recurrent in vitro fertilization failures, with prevalence rates reaching up to 57.55%. Interestingly, as many as 30% of couples facing difficulties in conceiving are found to have unexplained infertility. Recent research indicates a link between chronic endometritis (CE) and issues related to unexplained infertility, as well as complications during pregnancy and childbirth. Objective: This review seeks to enhance understanding of the epidemiology, causes, pathophysiology and diagnosis of CE, its impact on reproductive outcomes, and the effect of its treatment on pregnancy rate Method: We conducted a search on Google Scholar and PubMed to investigate the effect of chronic endometritis treatment on pregnancy rate in unexplained infertility. Our review included only the most comprehensive studies published between January 2003 and 2019. Conclusion: chronic endometritis is commonly found in cases of unexplained infertility & its treatment improves the rate of spontaneous pregnancy.