Background: Cardiovascular disease (CVD) remains the primary cause of mortality for patients with early-onset chronic kidney disease (CKD), despite improvements in subject survival over the past several decades. Additionally, there is a dearth of research on CVD in children. Objectives: This research aimed to study the electrocardiographic abnormalities and Holter findings in children with predialytic CKD. Subjects and methods: A cross-sectional study that was conducted on 50 children with predialytic CKD through the period from November, 2022 to November, 2023. Data were collected from children through personal interviews with their parents or care givers and assessment of their anthropometric measures, laboratory investigations, echocardiography, ECG and holter study. Results: CKD stage 5 showed the highest percentage of abnormalities in Echocardiography and ECG results, which showed a statistically significant relationship to the stages of CKD. Left ventricular hypertrophy was the main echocardiographic abnormality while prolonged QTc duration and sinus tachycardia were the main ECG abnormalities. There was a statistically significant variation between CKD stages as regards heart rate variability parameters, with CKD stage 5 participants having the lowest heart rate variability parameters as regards PNN50, rMSSD, SDNN at 5.078 ± 8.12, 29 ± 20.89, and 34.11 ± 17.55 respectively. Also, there was statistically significant difference between CKD stages as regards Hct and phosphorus level. Conclusion: Children in the fifth stage of chronic renal disease had the highest incidence of abnormalities observed by echocardiography, electrocardiography, and holter monitoring where patients in CKD stage 5 had the lowest heart rate variability values.