Background: Artificial intelligence techniques have recently made a significant impact on the healthcare industry. AI encourages physicians to use a broader approach to managing diseases, enhance treatment strategies, and support patients in more effectively managing and satisfying their extended course of treatment. Objectives: To determine the extent of perception and opinion of physicians in Egypt regarding artificial intelligence (AI). Subjects and Methods: An analytical cross-sectional study was carried out among physicians working in Beni-Suef hospitals, Beni-Suef City. Results: 249 physicians who were working in Beni-Suef hospitals took part in the present study with mean age (33.25± 9.48), most of the study participants heard about AI before. Only 21.7% of participants used AI before, nearly half of participants were not worried that they would be replaced by AI in their jobs in the future. There was a statistically significant difference in opinion score among people who were worried that AI would replace them in their job and people who were not, through a box plot figure. Conclusions: The study declared the opinion of physicians towards AI, as over 50% of those involved agree that AI use will reduce the overload of physicians. AI encourages physicians to use a broader approach to managing diseases, enhance treatment strategies, and support patients in more effectively managing and satisfying their extended course of treatment.