Background: Determining the risk factors of stone residual is critical in order to assist urologists in determining the potential results of retrograde intrarenal surgery (RIRS) and whether or not the patient will require further intervention following RIRS. Aim: This study aimed to evaluate the efficacy and safety of RIRS for the treatment of renal stones and to analyze the predictive factors for stone-free rates. Methods: This interventional prospective cohort study was conducted over a period of 18-months from July 2021 to January 2023. Two hundred patients suffering from renal stones were chosen from The Outpatient Clinics of Urology Departments, Helwan University Hospitals and Ain Shams University. Stone-free predictive criteria were evaluated. Results: Stone size, number, and location, as well as surgeon's experience, are crucial indicators of how well a treatment will work. Furthermore, it was discovered that the Resorlu-Unsal stone score (RUSS) was a trustworthy method for estimating the possibility of residual stones following RIRS. Conclusion: Surgeons can use predictive factors of stone-free information to more effectively choose patients for RIRS and modify therapy regimens to maximize results. The results further emphasized how crucial it is to perform RIRS procedures with precise technique and close attention to the patient's and the stone's features in order to reduce the possibility of residual stones.