Background: Histologically confirmed hepatocellular carcinomas (HCC) account for 90% of all hepatic malignancies and are notoriously fatal. Because of neovascularization, its blood supply is greater than that of the surrounding hepatic tissue. In order to diagnose HCC early and monitor its progress after surgery, a noninvasive technique called CTP, or computed tomography with perfusion imaging, measures the blood flow characteristics of the tumor and compares them to the surrounding tissue. Objective: To assess if CTP is a useful diagnostic method for identifying HCC for early surgical intervention and post-therapeutic assessment. Patients and Methods: Screening clinical trial study for patients who had HCC according to inclusion and exclusion criteria. 250 patients were included in the study. Results: Triphasic yields invisible results lesions were (20%) and visible lesions were (80%) of triphasic results. Regarding perfusion parameters, patients were (6%) negative and (94%) positive. CT perfusion was more sensitive and was 100% specific in the early detection of HCC lesions for early surgical intervention and also for follow-up after surgery to detect the recurrence if the positive predictive value was high, which means a high percent of true positive results and a small percent of false positive results. Conclusion: When it comes to evaluating surgical interventional techniques for HCC and making an early diagnosis, CTP is a specialized and secure imaging method.