Background: Benign prostatic hyperplasia (BPH) is a prevalent condition among older men, often resulting in bladder obstruction. Goal: This study focuses on evaluating the efficacy and recovery associated with Transurethral Bipolar Enucleation and Resection of the Prostate (TBERP) for treating BPH in patients with large prostates (>80 g). Patients and Methods: A randomized prospective clinical trial was conducted on BPH patients over 50 years old with a prostate volume >80 mL, maximum flow rate (Qmax) >15 mL/s, and International Prostate Symptom Score (IPSS) >8, meeting established surgical indications. Patients underwent TBERP, with intraoperative blood loss, operation time, resected prostatic tissue weight, postoperative catheterization, and hospital stay period being recorded. Additionally, patients were assessed for IPSS, post-voiding residual urine, prostate volume, and complications (including urinary retention, urinary tract infection, irritative symptoms, urinary incontinence, urethral stricture, and bladder neck contracture) over a three-month follow-up period. Results: The study enrolled 32 patients with a mean age of 62.63 years. TBERP demonstrated effective outcomes with minimal complications during the three-month follow-up period. The mean catheterization period was 5.09 days, and the mean hospital stay was 2.13 days. The mean operative time was 121.88 minutes, and the mean weight of resected prostatic tissue was 43.94 g. Conclusion: TBERP is a safe and effective treatment for BPH in patients with large prostates, offering significant benefits in terms of reduced bleeding and quicker recovery compared to traditional methods. This study underscores the potential of TBERP in enhancing patient outcomes in BPH surgery.