Beta
ManageSearchChatDiscover
369500

Ameliorative Effect of Parsley and Pumpkin Seeds Oils against Cosplatin Induced Hepatorenal Injury in Male Albino Rats (Physiological and Histological Study)

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Cisplatin is a widely used chemotherapeutic agent with significant hepatotoxic and nephrotoxic side effects. Objective: This study aimed to investigate the protective effects of parsley oil (PO) and pumpkin seed oil (PSO) against cisplatin-induced organ toxicity in male albino rats. Methods: A batch of male albino rats weighing between 160 and 200 grams was divided into four groups. Group 1 functioned as the control group. Group 2 was administered a solitary dose of cisplatin at a dosage of 7.5 mg per kilogram of body weight, intraperitoneally. Groups 3 and 4 were pre-treated with PO or PSO (0.1 ml/kg BW, orally) for ten days and then received cisplatin on the sixth day. On day 11, blood samples were obtained for biochemical examination. Histopathological examination of kidney samples was also conducted. Results: Cisplatin administration significantly elevated ALT, AST, urea, and creatinine levels, indicating liver and kidney damage. Pre-treatment with PO and PSO significantly mitigated these effects, normalizing the biochemical markers. Histopathological analysis supported these findings, showing reduced tissue damage in PO and PSO groups. Conclusion: Parsley oil and pumpkin seed oil provided defense against liver and kidney damage caused by cisplatin in rats, suggesting their potential as adjuncts in chemotherapy.  

DOI

10.21608/ejhm.2024.369500

Keywords

Cisplatin, Hepatotoxicity, Nephrotoxicity, parsley oil, Pumpkin seed oil, antioxidants, Chemotherapy

Volume

96

Article Issue

1

Related Issue

48863

Issue Date

2024-07-01

Receive Date

2024-07-27

Publish Date

2024-07-01

Page Start

2,672

Page End

2,679

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 96_Issue 1_Pages 2672-2679.pdf

PDF . 1.2MB

Link

https://ejhm.journals.ekb.eg/article_369500.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=369500

Order

51

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Ameliorative Effect of Parsley and Pumpkin Seeds Oils against Cosplatin Induced Hepatorenal Injury in Male Albino Rats (Physiological and Histological Study)

Details

Type

Article

Created At

24 Dec 2024