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A Comparative Study between Oxytocin Intravenous Bolus versus Oxytocin Intravenous Bolus and Infusion for Control of Blood Loss at Elective Cesarean Section

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Last updated: 03 Jan 2025

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Abstract

Background: One of the most crucial steps taken to stop postpartum hemorrhage (PPH) is to take a uterotonic medication as soon after delivery. Objective: Our main objective was to determine which method was better for controlling intraoperative and early postoperative bleeding after an elective Cesarean section (CS) whether intravenous (IV) oxytocin bolus or oxytocin bolus with infusion. Patients and methods: Randomized controlled study that included 214 women who were scheduled for an elective Cesarean section after 38 weeks were divided into two equal groups and given an IV slow bolus oxytocin 5 IU and a placebo infusion (500 ml of normal saline over 4 hours)(Control group) or an IV slow bolus oxytocin 5 IU and an oxytocin infusion (40 IU in 500 ml of normal saline over 4 hours) (Study group). Following fetal delivery, all patients were administered the study medication. Results: The need for additional uterotonics was statistically higher in group A than in group B 26 (24.3%) versus 14 (13.1%). While the estimated blood loss was statistically insignificant between both groups (691.9 ± 233.6 ml in group A versus 543.1 ±179.4 ml in group B. Conclusion: Following IV oxytocin slow bolus during an elective Cesarean section, an additional oxytocin infusion was not superior to IV oxytocin slow bolus alone in reducing the operative blood loss but it may reduce the postoperative need for additional uterotonics  

DOI

10.21608/ejhm.2024.363734

Keywords

Postpartum Hemorrhage, oxytocin, cesarean section, Third stage

Volume

96

Article Issue

1

Related Issue

48863

Issue Date

2024-07-01

Receive Date

2024-07-04

Publish Date

2024-07-01

Page Start

2,403

Page End

2,409

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_363734.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=363734

Order

13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

A Comparative Study between Oxytocin Intravenous Bolus versus Oxytocin Intravenous Bolus and Infusion for Control of Blood Loss at Elective Cesarean Section

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Type

Article

Created At

24 Dec 2024