Background: Enhanced recovery programs (ERP) have emerged to enhance surgical outcomes and decrease expenses. However, these are still opposed by the traditional measures in the treatment of colorectal carcinoma Objectives: This study aimed to compare laparoscopic versus open left-side cancer colon resection under the guidelines of ERP. Subjects and methods: sixty-two patients with left side cancer colon were divided into two equal groups: group (A) received laparoscopic colectomy (LC) and group (B) received open colectomy (OC). ERP were applied. Follow-up was planned for 1 month for the early outcomes. Results: the mean age of the included subjects was 49.2 ± 6.23 and 47.8 ± 6.9 years in LC and OC groups respectively. There was a significantly less hospital stay in LC group when compared with OC group (P=0.001). Significantly more pain was reported in OC Group (P=0.001%). There was a significant difference regarding postoperative complications where Postoperative nausea and vomiting (PONV), ileus, wound infection and wound dehiscence were statistically higher in OC group when compared with patients who received LC (P=0.001). Conclusion: Laparoscopic left-sided colectomy, when establishing ERP, is safer, more dependable, easier to use, and more appropriate than open left-sided colon cancer surgery—especially when performed by skilled surgeons with fewer postoperative problems and shorter hospital stays.