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361998

Comparative Study between Chromitron Versus Metformin as an Adjuvant Agent for Ovulation Induction with Letrozole in Patients with Polycystic Ovary Syndrome

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Last updated: 03 Jan 2025

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Abstract

Background: Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine condition affecting many young women globally. Metformin being the primary treatment for type two diabetes may affect ovulation. Objective: To evaluate the impacts of supplementation of chromium picolinate with induction of ovulation in PCOS on those of metformin supplementation, focusing on the effects on the response of the ovary, sensitivity of insulin, & rate of pregnancy. Materials & Methods: This was a double-blinded and prospective research that was carried out on 120 women who were undergoing ovulation induction and were separated into two groups, each consisting of 60 infertile women who met the Rotterdam criteria for PCOS in 2017. The study was conducted at Damanhour Medical National Institute from August 2023 to January 2024. Results: There wasn't significant variance among the two groups in terms of demographic characteristics, cumulative pregnancy, & ovulation rate. We started the pretreatment at month-1, made a change from month-1 to month-3, and continued the change from month-1. Fasting insulin during the follow-up was considerably lower in comparison with the baseline level in each group. Compared to the chromium group, the metformin group was noticeably lower. Conclusion: We advise some PCOS patients to switch from metformin to chromium picolinate because it was less likely to cause side effects, was better tolerated, and did not significantly differ from the other group regarding rates of pregnancy and ovulation.  

DOI

10.21608/ejhm.2024.361998

Keywords

Clomiphene citrate, Chromium Picolinate, polycystic ovary syndrome, Metformin

Volume

95

Article Issue

1

Related Issue

46984

Issue Date

2024-04-01

Receive Date

2024-06-26

Publish Date

2024-04-01

Page Start

2,283

Page End

2,288

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 95_Issue 1_Pages 2283-2288.pdf

PDF . 672.6kB

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https://ejhm.journals.ekb.eg/article_361998.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=361998

Order

153

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Comparative Study between Chromitron Versus Metformin as an Adjuvant Agent for Ovulation Induction with Letrozole in Patients with Polycystic Ovary Syndrome

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Article

Created At

24 Dec 2024