Background: Levonorgestrel-only Emergency Contraception (EC) prevents fertilization by inhibiting ovulation. Using Emergency Contraception within five days of intercourse may prevent more than eighty-five percent of pregnancies. Aim: This study aimed to evaluate the effectiveness of levonorgestrel administered orally vs. vaginally as an emergency contraceptive. Patients & methods: This comparative, possible, randomized research has been conducted on one hundred women with regular cycles at Damanhur Medical National Institute from September 2023 until February 2024. Women were split into two groups: First group included 50 women who took 1.5 mg of levonorgestrel orally (two Contraplan II tablets). Second group contained 50 women who received 1.5 mg of levonorgestrel vaginally (two Contraplan II tablets). Results: No statistically significant variances were found among the examined groups regarding general characteristics, general assessments, anthropometrics, CBC, and profiling of coagulation. A statistically significant variance had been demonstrated among the examined groups regarding the plasma levels of levonorgestrel, platelets, BT, CT, PT, nausea, stomach discomfort, headaches, and vomiting. The vaginal group had a lower pregnancy rate. Conclusion: We concluded that levonorgestrel vaginal administration is more suitable, effective, and safer as an emergency contraceptive compared to oral administration. So, we suggest using levonorgestrel vaginal administration as an EC rather than oral administration.