Background: The pathogenesis of hypertension (HTN) relates to immune system as well as inflammatory indicators such C-reactive protein, TNF-α, and interleukin-6 (IL-6). Objective: To ascertain the connection between serum omentin-1 and IL-6 in obese, hypertensive and in hypertensive nephropathy patients. Patients and Methods: This case-control research was done on 126 patients between 18 and 60 years of age, both sexes, hypertensive patients, hypertensive nephropathy patients, and overweight obese subjects. Serum omentin-1 and serum IL-6 were quantified in all patients. Results: A statistically significant inverse relation was noted between serum omentin-1 and age, systolic, diastolic blood pressure, urea, creatinine. A statistically significant positive relation has been observed between serum omentin-1 and estimated glomerular filtration rate (eGFR). The best cutoff points of serum omentin-1 and IL-6 for diagnosis stage III and IV hypertensive nephropathy respectively was ≤215, ≥6.7 with area under curve 0.721, 0.785, sensitivity 66.7%, 81%, specificity 71.4%, 61.9% and overall accuracy 69% (p=0.014) and 71.4% (p=0.002). Statistically significant variation was observed between groups under study concerning age, creatinine, urea and serum IL-6 (significantly greater in hypertensive nephropathy stage III and IV subgroup). Conclusions: Omentin-1 concentrations decreased significantly with increasing body weight, as well as with HTN; mainly hypertensive nephropathy and higher stages of HTN. Furthermore, IL-6 increased significantly in obese, hypertensive and hypertensive nephropathy patients.