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349824

Comparing the Efficacy of Carbetocin during an Elective Cesarean Section in Preventing Postpartum Hemorrhage in Obese versus Non–Obese Women

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Last updated: 03 Jan 2025

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Abstract

Background: One of the most frequent preventable causes of maternal death is still obstetric hemorrhage. The World Health Organization advises using carbetocin to avoid post-partum hemorrhage in all pregnancies, especially in situations when oxytocin is not available. Objective:This study aimed to assess how well carbetocin worked in obese full-term pregnant women to improve uterine contraction and reduce blood loss. Subjects and methods: Between July 2023 and October 2023, 150 pregnant women who were admitted for an elective cesarean section at term, were included in this prospective randomized controlled clinical study. Two equal groups of pregnant women were formed: 75 women in the study group had a body mass index (BMI) of at least 30 kg/m2and 75 women in the control group had a BMI of less than 30 kg/m2. Following cord clamping, each woman received a one-minute intravenous bolus of 100 mcg carbetocin as the research medication. Estimation of blood loss was done by measuring the volume of blood of intraoperatively utilized blood-soaked towels and comparing preoperative and 24-hour post-delivery hemoglobin and hematocrit values. Results:Among the groups being studied, no statistically significant difference was found with respect to hemoglobin level, hematocrit level, uterine tone, mean weighted blood loss, or estimated blood loss at birth. Neither the requirement for blood transfusions nor the adverse effects of the medication varied significantly between the groups under study. No cases indicated that more uterotonic medications were required. Conclusion: Obesity does not appear to have an impact on carbetocin's ability to prevent PPH.  

DOI

10.21608/ejhm.2024.349824

Keywords

Postpartum Hemorrhage, carbetocin, Obesity

Volume

95

Article Issue

1

Related Issue

46984

Issue Date

2024-04-01

Receive Date

2024-04-11

Publish Date

2024-04-01

Page Start

1,519

Page End

1,525

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_349824.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=349824

Order

37

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Comparing the Efficacy of Carbetocin during an Elective Cesarean Section in Preventing Postpartum Hemorrhage in Obese versus Non–Obese Women

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Type

Article

Created At

24 Dec 2024