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348395

Study of Interleukin 33 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis

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Last updated: 24 Dec 2024

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Abstract

Background:Allergic rhinitis (AR) is a chronic illness, which most people are afflicted by. Objective: To evaluate the expression of interleukin-33 in patients presenting with allergic rhinitis and nasal polyposis. Patients and Methods:This study was carried out on 50 patients aged from 15 to 40 years old, both sexes, and 25 healthy volunteers matched in age and sex. Patients were allocated into two groups: Case group n= 50 and control group n= 25, then the case group was further subdivided into equal two groups: nasal polyposis group n= 25, and AR group n= 25. All patients were subjected tolaboratory investigations, DNA extraction, measurement of DNA concentration, and single nucleotide polymorphism detection. Results: The most predominant genotype in sinusoidal nasal polyps was CT (60%) in both tissue and serum. Conclusions: Il 33 genotype (rs11792633) wasn't associated with allergic rhinitis and nasal polyps.  

DOI

10.21608/ejhm.2024.348395

Keywords

Interleukin 33, Gene polymorphism, Allergic Rhinitis, nasal polyposis

Volume

95

Article Issue

1

Related Issue

46984

Issue Date

2024-04-01

Receive Date

2024-04-01

Publish Date

2024-04-01

Page Start

1,291

Page End

1,296

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 95_Issue 1_Pages 1291-1296.pdf

PDF . 440.3kB

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https://ejhm.journals.ekb.eg/article_348395.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=348395

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study of Interleukin 33 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis

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Article

Created At

24 Dec 2024