Background: Diabetic patients often experience symptoms that originate from the gastrointestinal tract. Various agents, including gastric motility abnormalities and Helicobacter Pylori (HP) infection, are believed to be responsible for these changes. Limited and controversial data are available on the prevalence of HP in those studied cases & the correlation between HP infection & diabetic control is not well-defined. Aims: This study aimed to examine the prevalence of HP in diabetic patients with dyspepsia and to evaluate the link between H. Pylori infection and glycemic control. We evaluated the prevalence of HP in type 1 and type 2 diabetic patients with ulcer and non-ulcer dyspepsia (NUD) and their relationship to diabetes (DM) control. Subjects and Methods: In this study, 150 subjects were selected and were split into three groups: Group 1: type 1 diabetes, group 2 (type 2 diabetes), and group 3 (non-diabetic).  Patients were asked for dyspeptic symptoms. Endoscopy of the upper gastrointestinal tract was performed for all patients to confirm or exclude peptic ulcer. HP infection was diagnosed by rapid urease test (RUT) and histopathology (HPE), and glycemic control was measured by fasting (FBS), postprandial blood sugar (PPBS), and Glycated hemoglobin (HbA1c). Results: HP prevalence in diabetic patients was significantly higher than in the control group and its presence was likely associated with poor glycaemic control. Conclusions: Diabetics are at high risk of HP infection. HP infection may be related to inadequate glycemic control and should be considered for eradication therapy.