Background: Sepsis has been considered as a major cause of morbimortality worldwide. The mortality rate of severe sepsis is 25%, representing about 40% of hospital mortality. Sepsis-induced cardiac dysfunction (SICD) is encountered in the intensive care unit (ICU), and its prevalence in septic cases ranges from 10 to 70%. Such discrepancies among researches are mainly owing to the absence of well-established diagnostic criteria. Objective: To investigate if cardiac dysfunction as evidenced by positive troponin (cTnI) and left ventricular systolic and diastolic functions can predict bad outcome in non-cardiac patients with severe sepsis and/or septic shock. Patients and Methods: This was a prospective observational cohort study carried out in Emergency Department (ED), Mansoura University on 100 patients, adults, non-cardiac, non-surgical patients, who were presented with severe sepsis over a period of 1 year from July 2022 to July 2023. Results: 55% of the included patients were positive troponin. Troponin was a statistically significant independent predictor of mortality, bad outcome and need for vasopressor among studied cases. Possible predictors of mortality showed that lower albumin, lower ejection fraction and positive troponin were statistically significant predictors of mortality among studied cases. Conclusion: High troponin levels may be detected in non-cardiac patients with sepsis and this group according to new guidelines are considered stage-B pre heart failure patients. Troponin is a statistically significant independent predictor of mortality, bad outcome and need for vasopressor among studied cases.