Introduction: The gradual development of diffuse anterior knee pain is characteristic of patellofemoral pain (PFP), which is made worse by activities that put stress on the patellofemoral joint, such as running, stair climbing, and squatting. While 23% of the overall population has PFP, athletes can have a prevalence of 35%. Objectives: To identify the prevalence and potential risk factors of patellofemoral pain as well as knee pain in the heavily obese people living in Cairo. Subjects and methods: This study was carried out in Great Cairo, Egypt. The SNAPPS questionnaire was utilized.  910 participants were male and female young adults, ranging in age from 18 to 40. Results: The prevalence of PFP was shown to be 42.4%. Males had a prevalence of 42.2% for PFP and females 42.6%. With 127 individuals reporting knee pain, the overall prevalence of the condition was determined to be 14%. In males, 17.3% of the population experienced knee pain, while in women, it was 11.9%. Chi-squared test revealed that all risk factors (body mass index, job, marital state and age) were significantly linked with prevalence of patellofemoral (p-value<0.05) and knee pain (p-value<0.05) except gender that was insignificantly associated with patellofemoral pain (p-value=0.46). Conclusions: Obese people living in Cairo, Egypt, had a relatively significant incidence of PFP and knee pain. People under the age of 40 had a greater incidence of PFP and knee pain in comparison with those in older age groups.