Background: It is well-known that there's more risk of neonatal respiratory distress with babies born by cesarean delivery than vaginal delivery, regardless of fetal gestational age. Objectives:The aim of this work was to evaluate if different modes of anesthesia affect fetal acid-base for cesarean sections. Patients and methods:  This cross-sectional study was conducted on newborns of 150 pregnant women of full-term babies aged 20 to 35 years with no previous maternal medical condition, undergoing elective caesarean section. Patients were allocated into two equal groups; SA group where cesarean sections were done under spinal anesthesia and GA group where cesarean sections were done under general anesthesia. All neonates underwent history taking, and postnatal history including general neonatal examination, Apgar score, neurological examination [Mental status, sensory perception, and reflexes] and systemic examination. Cord blood samples were taken from participant newborns, and immediately after birth and the taken samples were sent for blood gas analysis. Results: There was a significant strong positive correlation between the outcomes and PH, PO₂, and PCO₂. Regarding univariate correlations and multivariate correlations, there was a significant strong positive correlation between the outcomes and PH, PO₂ and PCO₂ (P value= <0.0001). Conclusions: It could be concluded that umbilical cord arterial blood gas values, Apgar score (at 1, 5 and 10 min after birth) and neonatal asphyxia are comparable between the two different modes of anesthesia (spinal and general). Moreover, there are significant strong positive correlations between the outcomes and PH, PO_2, and PCO₂, and they also are strong predictors of the neonatal outcome.