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337172

Non-Invasive Prediction of Gastric Varices in HCV Related Cirrhosis

Article

Last updated: 24 Dec 2024

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Abstract

Background: Gastric varices may bleed severely and are often associated with poor outcomes. The Baveno VII consensus encouraged non-invasive tests (NITs) to identify patients at risk of acute upper GI bleeding (AUGIB) due to ruptured varices and to avoid unnecessary screening upper GI endoscopic examination (UGIE). Recently, various NITs have been demonstrated as simple and non-invasive predictors of the presence of esophageal varices (EVs) and gastric varices (GVs) in patients with liver cirrhosis. Objectives:The current work aimed to evaluate the NITs that could predict the presence of GVs in patients with HCV related liver cirrhosis. Patients and Methods: 260 adult patients with HCV-related cirrhosis who were admitted for UGIE for either screening for varices or management of AUGIB were enrolled. Various NITs were calculated. Results: Liaoning score at a cutoff value > - 0.1635 was a statistically significant predictor of GVs with sensitivity=78.6%, specificity = 60.1%, positive predictive value (PPV) = 27.5 %, false discovery rate (FDR) = 72.5%, negative predictive value (NPV) = 93.6 %, false omission rate (FOR) = 6.4% & accuracy= 63.1%. RLLD at a cutoff ≤ 9.75 cm was a statistically significant predictor of GVs with sensitivity=73.8%, specificity= 54.1%, PPV= 22.3%, FDR= 77.7%, NPV= 90.9 %, FOR= 9.1% & accuracy= 54.2%. On multivariate regression analysis, Liaoning score & RLLD were significant predictors of GVs in patients with HCV related cirrhosis. Conclusion: Liaoning score & RLLD are significant predictors of GVs in HCV Egyptian cirrhotic patients with very high negative predictive value & very low false omission rate.  

DOI

10.21608/ejhm.2024.337172

Keywords

Liver cirrhosis, Chronic hepatitis C, gastric varices, Esophageal varices, Non-invasive tests

Volume

94

Article Issue

1

Related Issue

45268

Issue Date

2024-01-01

Receive Date

2024-01-18

Publish Date

2024-01-01

Page Start

322

Page End

330

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_337172.html

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https://ejhm.journals.ekb.eg/service?article_code=337172

Order

47

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Non-Invasive Prediction of Gastric Varices in HCV Related Cirrhosis

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Type

Article

Created At

24 Dec 2024