Background: The widespread chronic illness known as gastroesophageal reflux disease (GERD) significantly lowers quality of life (QOL). Additionally, reflux esophagitis and occasionally serious side effects including ulceration, strictures, Barrett's mucosa, and esophageal cancer can be brought on by gastroesophageal reflux disease (GERD).   Objective: To determine the clinical effectiveness of endosural suturing using a gastroscope in patients with refractory GERD. Patients and methods: This is prospective research that was conducted at Ain Shams University Hospitals' Gastroenterology Outpatient Clinic and Endoscopic Centre. The research was carried out between September 2019 and December 2020 on 25 adult patients with Hiatus hernia or recalcitrant GERD. Results: After the procedure, 2 (8%) had heart burn, 1 (4%) had regurgitation, 0 (0%) had asthma, 0 (0%) had chronic cough, 0 (0%) had laryngitis, and 0 (0%) had hoarseness. Regarding the severity of symptoms, there was a highly statistically significant difference between the pre- and post-treatment periods. In our investigation, we determined that the mean Hb was 12.89 (± 0.80 SD), the mean RDW was 13.40 (± 0.95 SD), the mean number of platelets (*1000) was 239.76 (± 59.92 SD), and the mean RBCs was 5.19 (± 0.51 SD) based on CBC data. The Gastrointestinal QOL Index showed a very statistically significant difference between the pre- and post-procedure states. Based on our own research, we discovered that the difference in Hill's grade before and after treatment was extremely statistically significant. Conclusion: According to our study, endoscopic suturing of the gastroesophageal junction significantly improves QOL following the treatment, significantly lessens the intensity of symptoms following the procedure, and significantly improves reflux management for up to six months.