Background: Playing violent games puts the body in a state of stress because of the situation you face. Children neglect the body reaction, which is severe and, in some cases may leads to death, due to the impairment that happens in vagal nerve activity, leading to dysregulation of inflammatory processes and cardiovascular disease, also addicting playing violent video games can affect children's musculoskeletal health especially at the cervical region due to staying in a fixed position for long times focusing on the screen. Objective: To determine the effect of selected physical therapy program on heart rate variability and cervical angle in violent video game addicted children. Subjects and Methods: Forty children from both sexes were selected randomly from Cairo schools and were classified into two equal groups: group A (control group) consisted of 20 school aged children who were also addicted to play violent video games and group B (study group) consisted of 20 school aged children who were addicted to play violent video games, and they received selected physical therapy program.  Results: This study found a significant increase in heart rate variability (HRV) of group A compared with that of group B post treatment (p = 0.001), there was no significant difference in flexion angle between groups pretreatment (p = 0.59), there was a significant increase in extension angle of group A compared with that of group B post treatment (p = 0.003). Conclusion: Selected physical therapy program in the form of aerobic exercise combined with relaxation technique improved the cardiac rhythm and improved neck extension range of motion (ROM).