Background: One of the most common microvascular complications of diabetes is neuropathy. Objective: This study aimed to compare the impact of intermittent pneumatic compression (IPC), high-frequency vibration (HFV), and balance program on nerve conduction velocity (NCV) as well as balance performance in patients with diabetic polyneuropathy. Patients and methods: Sixty female patients had lower limb diabetic polyneuropathy (DPN). Their ages ranged from 50 to 60 years. They were randomized into 3 groups of the same number (n=20). The vibration group received plantar, ankle, and cuff HFV. The compression group received lower limbs IPC, and the exercise group received the balance exercise program. The trial was for 12 weeks (3 sessions/week). NCV, Toronto clinical scoring (TCS), and Berg Balance Scale (BBS) were assessed at baseline and after treatment. Result: The study demonstrated that all the three groups (HFV, IPC, and exercise) had significant improvement from pre- to post-treatment, with no significant differences among them. The TCS decreased by 17.8%, 11.2%, and 14.8% respectively, in favor of the HFV group. The percentage of improvement of the BBS was 10.8%, 13.04 and 10.6 % respectively for the IPC group. The HFV and IPC groups showed better motor and sensory NCV improvement than the exercise group. Conclusions: The local HVF andIPC have almost the same positive impact on NCV and different quality-of-life issues for DPN as relieving pain and paresthesia, improving proprioception, and promoting functional balance better than the exercise group.