Background: Diabetes mellitus (DM) is a prevalent systemic ailment. The incidence of this condition varies from 8.3% to 11.6% among different ethnic groups in the general population. Objective: The objective is to compare the subfoveal choroidal thickness between diabetic patients without retinopathy and healthy individuals, utilizing Optical Coherence Tomography (OCT) as the primary diagnostic tool. Individuals and Methods: This study was conducted on 40 individuals who attended the Ophthalmology outpatient Clinic at Al-Zahraa University Hospital. Results: The mean age of the cases ranged between 18 and 53 year (mean ± SD was 37.65 ± 6.91 years. Twenty-five were females (62.5%) and 15 were males (37.5%). The mean subfoveal choroidal thickness (SFCT) in healthy individual was 272±13.79 (μm), while in diabetic patients without retinopathy it was 269±12.1 (μm). In our study there was non-statistically significant difference in right, left and average SFCT found between the patients group and the normal group (p-values were 0.428, 0.805 and 0.529 (μm) respectively). Conclusion: Diabetes mellitus is amicrovascular systemic disease, so it affects choroidal circulation lately with development of diabetic retinopathy. Diabetic patients without retinopathy had no significant changes in the subfoveal choroidal thickness. Spectral domain optical coherence tomography with enhanced depth imaging is an objective, fast, reliable, high sensitive, and a non-invasive technique used for measurement of subfoveal choroidal thickness.