Background: Fractures of humerus shaft account for between one to three percent and 20 percent of all humeral fractures. Microinvasive Plate Osteosynthesis (MIPO) is a burgeoning therapeutic approach utilized to treat humeral shaft fractures. One of the primary advantages of MIPO is that it promotes fracture healing by maintaining soft tissue and periosteal circulation. Objective: The aim of the work was to determine the efficacy of bridge plating for humerus shaft fractures using the minimally invasive plate osteosynthesis method. Patients and Methods: This short-term research study included a total of 15 patients presented with a recent humeral shaft fracture, chosen from the Department of Emergency, Misr University Hospitals, and received care surgically with MIPO. Results: The present study showed that there was one patient had delayed union and no other postoperative complications. The MEPI scoring system. It is measured at patients' last follow-up. In the MIPO patients, 7 (46.7%) showed excellent results, 7 (46.7%) showed good results, 1 (6.7%) showed fair, and no case showed a poor outcome. According to the UCLA scoring system, 6 (40.0%) individuals showed excellent outcomes, 8 (53.3%) individuals showed good outcomes, 1 (6.7%) patient had a fair outcome, and no patient had a poor outcome. Conclusion: depending on the result of our research it can be concluded that the MIPO method should be considered as a good choice for surgical treatment of diaphyseal humerus fractures.