Background: About 25% of the general population suffers from the epidemic liver condition known as nonalcoholic fatty liver disease (NAFLD). Clinical phenotyping ranges widely including liver cirrhosis, advanced fibrosis, non-alcoholic steatohepatitis (NASH), and hepatic steatosis. Objective: We aimed to find out the link between H. Pylori infection and the risk of NAFLD. Patients and methods: This cross-sectional study was conducted on 80 patients presented with H-Pylori in Ain Shams University Hospitals during the period from September 2020 to June 2021. Patients were divided into 2 groups: Risky group according to one or more of the following (dyslipidemia, BMI>24.9, SBP>140, DBP>90) and non-risky group with no metabolic risk factors. Results: Our findings demonstrated a statistically significant link between H. pylori and the development of NAFLD. We also discovered that gender has no effect on the prevalence of NAFLD. Furthermore, we discovered that NAFLD is related with higher TG levels. High SBP and DBP were shown to be related with an elevated risk of NAFLD in our research. In our investigation, the levels of AST and ALT were considerably higher in the risky group patients than in the non-risky group patients. In terms of the degree of fibrosis in patients with NAFLD, we discovered that riskier patients had a higher risk of fibrosis. Conclusion: Our findings showed that H. pylori infection may play a role in the development of NAFLD. Taking into account the limitations of the case control research and the limited size of the population covered. Other metabolic risk variables such as dyslipidemia and obesity may have a substantial role in the development and progression of NAFLD.