Background: The D-dimer (DD) test can detect fibrinolysis with good specificity. Its irregularity is a result of the coagulation and fibrinolysis systems being overactive in vivo. Since disrupted hemostasis is linked to chronic liver illness, it's probable that clot lysis as well as coagulation problems are also present. Estimating DD might shed light on potential disruptions in the fibrinolytic process. Objective: We aimed to determine the connection between ascites and the hyper fibrinolytic condition in hepatic cirrhosis. We evaluated serum DD in cirrhotic cases with and without ascites. We also examined how spontaneous bacterial peritonitis (SBP) affected the DD content in serum and ascitic fluid (AF). Patients and methods: This prospective study was conducted on 60 patients from the Department of Internal Medicine in Minia University Hospital including patients hospitalized due to decompensated liver cirrhosis and ascites. First group included fifteen cases with hepatic cirrhosis and no ascites. Second group included fifteen cirrhotic cases with ascites. Third group included fifteen cirrhotic cases with ascites and SBP. Fourth group (Control group) included fifteen matched healthy individuals with no evidence of hepatic disorder. Results: There was a diagnostic performance of serum DD in diagnosing of SBP in cutoff point of serum d dimer > 491.5 ng/ml, and ascitic DD in a cutoff point of ascitic d dimer > 380.5 ng/ml predicting cirrhotic ascitic cases with SBP. Conclusions: Patients with SBP showed a substantial link between serum DD and AF DD, while patients with cirrhotic ascites without bacterial infection demonstrated no significant correlation. When used to diagnose SBP in cases with hepatic cirrhosis, DD performed well.